Paper in Nature communications!
ACP's Shona Wood and researchers from the University of Manchester and Edinburgh have recently published a paper in Nature communications showing how animals use the daily (circadian) clock to synchronise seasonal changes in physiology.
A short summary of the paper:
Timing is crucial for survival. Wild animals must adapt their physiology at the right time in relation to their changing environment, and this is even more important in strongly seasonal environments like the Arctic. Timing is about anticipating and responding to changes. For this, organisms have an internal calendar that tracks the seasons, but how this internal seasonal calendar is synchronised to the environment has been a mystery. Dr. Shona Wood and her team from UiT have been working together with research teams from the Universities of Manchester and Edinburgh to solve this mystery, and in this paper in Nature Communications, they demonstrate that animals use components of their daily clockwork to synchronise their internal seasonal calendar. However, these clock components can only work if their target genes can be accessed. For this, seasonal epigenetic changes have to take place altering the accessibility to these key genes and triggering a cascade of physiological changes to prepare for changing seasons. These results constitute a blueprint for circadian-based seasonal timekeeping in vertebrates, but it remains to be determined if these mechanisms are used in Arctic species, who appear to lack circadian organization of behavior. This is a part of ongoing research at UiT.
The first author, Dr. Shona Wood, is supported by the Tromsø Forskningsstiftelse starter grant. The research was funded by grants from the Biotechnology and Biological Sciences Research Council UK and a Human Sciences Frontier Programme.
Timing is crucial for survival. Wild animals must adapt their physiology at the right time in relation to their changing environment, and this is even more important in strongly seasonal environments like the Arctic. Timing is about anticipating and responding to changes. For this, organisms have an internal calendar that tracks the seasons, but how this internal seasonal calendar is synchronised to the environment has been a mystery. Dr. Shona Wood and her team from UiT have been working together with research teams from the Universities of Manchester and Edinburgh to solve this mystery, and in this paper in Nature Communications, they demonstrate that animals use components of their daily clockwork to synchronise their internal seasonal calendar. However, these clock components can only work if their target genes can be accessed. For this, seasonal epigenetic changes have to take place altering the accessibility to these key genes and triggering a cascade of physiological changes to prepare for changing seasons. These results constitute a blueprint for circadian-based seasonal timekeeping in vertebrates, but it remains to be determined if these mechanisms are used in Arctic species, who appear to lack circadian organization of behavior. This is a part of ongoing research at UiT.
The first author, Dr. Shona Wood, is supported by the Tromsø Forskningsstiftelse starter grant. The research was funded by grants from the Biotechnology and Biological Sciences Research Council UK and a Human Sciences Frontier Programme.
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ReplyDeletePhysiology is the science of life. It is the branch of biology that aims to understand the mechanisms of living things, from the basis of cell function at the ionic and molecular level to the integrated behavior of the whole body and the influence of the external environment.
At Harbor Compounding Pharmacy, we work one-on-one with your doctor to formulate a powerful customized solution for your toughest pain problems. Harbor Compounding Pharmacy provides complete facilitation and counseling Female sexual health.
ReplyDeletePhysiology is the science of life. It is the branch of biology that aims to understand the mechanisms of living things, from the basis of cell function at the ionic and molecular level to the integrated behavior of the whole body and the influence of the external environment.
At Harbor Compounding Pharmacy, we work one-on-one with your doctor to formulate a powerful customized solution for your toughest pain problems. Harbor Compounding Pharmacy provides complete facilitation and counseling Female sexual health.
ReplyDeletePhysiology is the science of life. It is the branch of biology that aims to understand the mechanisms of living things, from the basis of cell function at the ionic and molecular level to the integrated behavior of the whole body and the influence of the external environment.
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